The present study was designed to investigate effect of some Calcium Channel Blockers on Central Nervous System activities in terms of Isolation Combativeness and Suppression of Conditioned Avoidance Response. This present study was carried out over three different classes of CCB’s, namely Benzothiazipine, Dihydropyridine and Piperazine, to evaluate their control activities on Central Nervous System. For this purpose Diazepam served as control. All the above tests were carried out over Albino Rats. In case of isolation combativeness Diltiazem in all three doses viz.; 5mg/kg,10mg/kg,20mg/kg and Flunarizine and Nifedipine in a dose of 20mg/kg,10mg/kg respectively effectively calm down the animals. During screening of conditioned avoidance response; Diltiazem was effective in all the three doses viz. 5mg/kg, 10mg/kg, 20mg/kg. While Flunarizine and Nifedipine, were partly effective. Calcium channel blockers: Diltiazem, Flunarizine, Nifedipine in different doses: can affect central nervous system functions in different ways and can interact with some other drugs effective on central nervous system.
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