Effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of 0.5mg & 0.6mg Glibenclamide in diabetic rats
Traditional medicines derived from medicinal plants are used by about 60 per cent world population. Diabetes is an important human ailment officiating many from various walk of life in different countries including India. It providing to a major health problem, especially in the rural and subrural areas. Gymnema sylvestre R.Br. (Asclepiadaceae) is a herb distributed throughout the world. The leaves of the plant are widely used for the treatment of diabetes and as diuretic in India proprietary medicine. Gymnema sylvestre an Ayurvedic herb, came to be known as “destroyer of sugar” because, in ancient times, Ayurvedia physicians observed that chewing a few leaves of G. sylvestre suppressed the taste of sugar. It is used totally all over India for controlling blood sugar. This study was to determine effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of Glibenclamide in streptozotocin induced diabetic rats. Results have indicated the negative effect of Gymnema Sylvestre on pharmacokinetics but positive effect on pharmacodynamics of Glibenclamide.
Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989; 12:553-64.
Izzo A A. Herb-drug interactions: an overview of the clinical evidence, Fundamental & Clinical Pharmacology, 19, 2005; 1-16.
Tack CJJ, Smits P. Thiazolidineone derivative in type 2 diabetes mellitus. J. Med. 2006; 64(6): 166-172.
Thomsen RW, Rus A. Christensen S, Norgaard M, Sorensen HT. Diabetes and 30-day mortality from peptic ulcer bleeding and perforation. A Danish population-based cohort study. Diabetes Care. 2006; 29: 805–810.
Aditi C, Bhawani G, Agarwal PK, Shalini G. Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastro mucosal offensive acid-pepsin secretion. Indian J. Physiol. Pharmacol. 2009; 53(2): 137–1464.
Boehme MW, Autschbach F, Ell C, Raeth U. Prevalence of silent gastric ulcer, erosions or severe acute gastritis in patients with type 2 diabetes mellitus- a cross-sectional study. Hepatogastroenterology. 2007; 54: 643-648.
Patel K, Gadewar M, Tripathi R, Patel DK. Pharmacological and analytical aspects of gymnemic acid: a concise report. Asian Pac J Trop Dis. 2012; 2(5): 414-416.
Shivani Vaidya. Review on gymnema: an herbal medicine for diabetes management. Pharmacia. 2011; 1(2): 1-6.
Ankit Saneja, Chetan Sharma, Aneja KR, Rakesh Pahwa . Gymnema Sylvestre (Gurmar): A Review, Der Pharmacia Lettre, 2010; 2(1): 275-284.
John B Classen. Review of Evidence that Epidemics of Type 1 Diabetes and Type 2 Diabetes/ Metabolic Syndrome are Polar Opposite Responses to Iatrogenic Inflammation. Current Diabetes Reviews. 2012; 8(6): 413-418.
Farzana C., Muhammad H.R. Isolation and characterization of gymnemic acid from Indigenous Gymnema sylvestre. J APP Pharm, 2010; 3(2):60-65.
Reed, M.J., Meszaros, K., Entes, L.J., Claypool, M.K., Pinkett, J.G., Gadbois, T.M., Reaven G.M. (2000) A new rat model of type 2 diabetes: The fat-fed, streptozotocin- treated rat. Metabolism clinical and experimental, 2000; 49 (11): 1390-1394.
Thulesen, J., Orskov, C., Holst, J.J., Poulsen, S.S., Short term insulin treatment prevents the diabetogenic action of streptozotocin in rats. Endocrinology 1997; 138 (1): 62-68.
Talari, R.,Varshosaz, J., Mostafavi, S.A., Nokhodchi, A. Gliclazide Microcrystals Prepared by Two Methods of In Situ Micronization: Pharmacokinetic Studies in Diabetic and Normal Rats. AAPS PharmSciTech, 2010; 11 (2).
Shavi, G.V., Usha, Y.N., Armugam, K., Ranjan, O.P., Ginjupalli, K., Pandey, S., Udupa, N. Enhanced dissolution and bioavailability of gliclazide using solid dispersion techniques. International Journal of Drug Delivery 2010; 2: 49-57.
Navetabhishekam, S.N., Asad, M., Prasad, V.S. Pharmacodynamic interaction of Momordica charantia with rosiglitazone in rats, Chem Biol Interact. 2009; 177: 247–253.
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