Depression is the leading cause of disability with a prevalence of more than 20% worldwide. It is associated with change in mood, loss of pleasure, inability to concentrate, lack of energy, sleep disturbance, guilty and suicidal tendency. The exact mechanism of depression is not known till now, but many hypothesis were implicated in the pathogenesis of depression which includes monoamino, GABAergic, glucocorticoid, neurotrophic, inflammatory hypothesis. The present review emphasized on different hypothesis for better understanding the pathogenesis of depression and identifying potential targets for screening of drugs for antidepressant activity.
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