Back ground: Free radicals are chemical species possessing an unpaired electron which are generally very reactive. The role of free radicals has been implicated in the causation of several diseases such as liver cirrhosis, cancer, aging, arthritis, diabetes, etc. and the compounds that can scavenge free radicals have great potential in ameliorating these disease process. Medicinal herbs are considered to be good therapeutics since time immemorial. Kydia calycina Roxb., is a widely used ethnomedicinal plant in the north coastal districts of Andhra Pradesh, India, to treat various liver disorders, skin related problems and other common ailments. Method: The DPPH radical and superoxide radical scavenging activity of hydro-alcoholic extract, hexane, ethyl acetate and methanol fractions of aerial parts of Kydia calycina Roxb., was determined by the IC50 values of the selected plant extracts and ascorbic acid. The lower the IC50 value, the higher the free radical scavenging activity. Result: The mean IC50 values for DPPH radical with 80% hydro-alcoholic extract, hexane fraction, ethyl acetate fraction and methanol fraction of Kydia calycina aerial parts were found to be 73.5, 36.0, 23.0 and 25.9 g. Among the test results, ethyl acetate fraction showed better activity. The mean IC50 values for Superoxide radical with 80% hydro-alcoholic extract, hexane fraction, ethyl acetate fraction and methanol fraction of Kydia calycina aerial parts were found to be 30.2, 21.6, 18.7 and 25.9 g. Conclusion: The test results revealed, the methanol extract in general and ethyl acetate fraction in specific showed better activity. The results were found to be significant, validating the free radical scavenging activity of Kydia calycina .
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